Published-IP

We have identified the optimal stimulus pulsewidth for sacralneuromodulation based on chronaxie of motor responses to S3 sacral nerve stimulation in sheep.  The EMG responsesto SNM with different stimulation pulse widths were randomly examined using variable intensities from 0.1 V to 10 V. These data suggest that a similar motor response may be evoked in theEAS at pulse widths much shorter (62 µs – 74 µs) than the 210 µs typically used with SNM.  Shorter pulse widths translatedirectly to increased energy savings in the neurostimulator.  Method 1: This invention utilizes a simple device with afixed pulse width of 60 – 80 us (e.g. 70 us) with also possible fixed frequency of 10 Hz which is the optimal frequency for neuromodulation of bladder function.  The only adjustable parameter will bestimulation intensity, which would provide effective nerve stimulation and simple operation.  This method isprescreened on chronaxie for patients who have no neuropathology conditions.  Method 2: The stimulation pulsewidth could be programed forneuromodulation based on individual patients’s response to S3 nerve stimulation.   For example, the chronaxiemay vary based on condition of the nerve system of the patients and pulsewidth will be adjusted based on responses (e.g. EMG, sensation et al) to stimulation and maybe also the outcome (readout) of diseases (loopped control for example).  This method is useful for patients who have neuropathologyconditions.